Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProt release 2019_02

新疆十一选五开奖结果 www.6nbnc.cn Published February 13, 2019

Headline

Let’s twist again with Myo1D

At first glance, we look bilaterally symmetrical. Our left side appears pretty much the mirror image of the right one. For our internal organs, it’s a completely different story. For instance, our heart is on the left of our body, while the liver lies to the right. Macroscopic left-right patterning is only one aspect of an organism’s asymmetry. Actually all known life forms show asymmetric properties in chemical structures, as well as in macroscopic anatomy, development and behavior. However, not much is known about the nature of the link between molecular-level and macroscopic asymmetry.

Studies in Drosophila led to the discovery of a crucial role for an unconventional myosin, called Myo31DF or Myo1D, in left-right asymmetry. Myo1D inactivation in the fly can reverse handedness of the gut and testes. In a recent publication, Lebreton et al. have extended these observations, showing that ectopic expression of Myo1D in ‘naive’ tissues, i.e. devoid of left-right asymmetry, such as epidermis and trachea, was sufficient to drive laterality. In the larval epidermis, Myo1D expression induced dextral twisting of the whole larval body, which could rotate up to 180°, resulting in abnormal crawling behavior. In the trachea, pronounced right-handed twisting, with a spiraling ribbon shape with multiple turns, was observed instead of the smooth and linear conformation of the wild-type tissue. This asymmetry was also seen at the cellular level. In control conditions, epidermal cells were perpendicular to the anterior-posterior axis. In contrast, cells ectopically expressing Myo1D showed elongation and a clear shift in membrane orientation toward one side. Myo1D functions as an actin-based motor protein with ATPase activity and this activity was required for the establishment of left-right asymmetry. In vitro Myo1D caused actin filaments to move in anticlockwise circular motion, suggesting that the multiscale property of Myo1D emerges from its molecular interaction with F-actin.

Does this conclusion apply to vertebrates? This answer is not straightforward. Experiments in some vertebrates point to a role for MYO1D in left-right patterning. In Xenopus, MYO1D morpholino knockdown affected organ placement in over 50% of the morphant tadpoles. In Zebrafish, MYO1D plays a role in the formation of Kupffer’s vesicle, an organ that functions as left-right organizer during embryogenesis. However, in rat, MYO1D knockout didn’t lead to visceral situs inversus and caused no obvious motor defects, indicating that, at least in certain mammals, MYO1D is not involved in left-right body asymmetry.

As of this release, UniProtKB/Swiss-Prot MYO1D entries have been updated and are publicly available.

UniProtKB news

Removal of the cross-references to CleanEx

Cross-references to CleanEx have been removed.

Changes to the controlled vocabulary of human diseases

New diseases:

Modified diseases:

Changes to the controlled vocabulary for PTMs

New term for the feature key ‘Modified residue’ (‘MOD_RES’ in the flat file):

  • ADP-ribosyldiphthamide

RDF news

Change of URIs for Orphanet

For historic reasons, UniProt had to generate URIs to cross-reference databases that did not have an RDF representation. Our policy is to replace these by the URIs generated by the cross-referenced database once it starts to distribute an RDF representation of its data.

The URIs for the Orphanet database have therefore been updated from:

//purl.uniprot.org/orphanet/<ID>

to:
//www.orpha.net/ORDO/Orphanet_<ID>

If required for backward compatibility, you can use the following query to add the old URIs:
PREFIX owl:<//www.w3.org/2002/07/owl#>
PREFIX up:<//purl.uniprot.org/core/>
INSERT
{
   ?protein rdfs:seeAlso ?old .
   ?old owl:sameAs ?new .
   ?old up:database <//purl.uniprot.org/database/orphanet> .
}
WHERE
{
   ?protein rdfs:seeAlso ?new .
   ?new up:database <//purl.uniprot.org/database/Orphanet> .
   BIND,32))) AS ?old)
}

The dereferencing of existing //purl.uniprot.org/orphanet/<ID> URIs will be maintained.

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our 新疆十一选五开奖结果 to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
  • 湖口县公安局开展集中整治城区飙车行动 2019-03-19
  • 【高清】福州:体验身边的高科技 2019-03-18
  • 新疆伊犁:薰衣草香飘万里 “紫色经济”成产业 2019-03-17
  • 安踏、特步齐发澄清公告 称沽空报告不属实、具有误导性 2019-03-17
  • 曹建明:推进平安中国建设,确保国家长治久安、人民安居乐业 2019-03-16
  • 云南女子饲养小猴子5年 竟是国家一级保护动物熊猴 2019-03-16
  • 图解:习近平的《人民日报》情缘 2019-03-15
  • 是建立市场经济才搞市场经济,不是搞市场经济,我们如何正确认识这个问题? 2019-03-14
  • 全世界人民都要尊重人类社会发展规律即从过去资本主义社会财富私有制经过现代社会财富公有制和私有制并存而发展到未来共产主义社会财富公有制。 2019-03-13
  • 河南焦作市2018年面向国内外引进高层次急需紧缺人才公告 2019-03-13
  • 足球界最丑十大球星:小罗第4!鲁尼第3 里贝里仅第6! ——凤凰网房产 2019-03-12
  • 公安部严查制售高科技作弊专用器材犯罪 2019-03-11
  • 从唐老鸭到疯狂动物城:卡通毛皮七十年 2019-03-10
  • 文化山西:风华长城岁月歌 2019-03-09
  • 世卫组织更新《国际疾病分类》 游戏成瘾列入精神疾病 2019-03-09
  • 50| 971| 899| 937| 25| 774| 310| 906| 745| 591|