Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProt release 2018_06

新疆十一选五开奖结果 www.6nbnc.cn Published June 20, 2018

Headline

Neuronal express mRNA delivery service

In mammals, the activity-regulated cytoskeleton-associated protein ARC is a key regulator of synaptic plasticity, being involved in many aspects of synapse formation, maturation, and plasticity, as well as in learning and memory. ARC expression is known to be induced by synaptic activity and its mRNA accumulates at sites of local synaptic activity where it is locally translated.

ARC originates from the Ty3/Gypsy retrotransposon family and it has retained some retroviral features. Its protein architecture is remarkably similar to that of the capsid domain of human immunodeficiency virus (HIV) GAG protein. GAG proteins are essential for viral infection. They can self-assemble to form capsids and encapsulate genomic RNA via direct sequence-specific interactions. At first glance, these properties do not seem crucial for eukaryotic proteins, but two recent studies unravel a quite unexpected means of neuronal communication, that is reminiscent of viral infection.

The intriguing observation was that ARC protein and mRNA are not only present at synapses, but also enriched in extracellular vesicles (EVs) released by neurons. These EVs are endocytosed by target cells, where ARC mRNA is postsynaptically translated, as has been described both at the Drosophila neuromuscular junction (NMJ), between motor neurons and muscles, and in rat hippocampal neurons. How is this achieved? Presynaptic ARC proteins bind the 3'-UTR of ARC mRNA, oligomerize and form capsid-like structures, in which the mRNA is packaged. These eukaryotic ‘capsids’ are then released by neurons in EVs and they mediate ARC mRNA transfer into postsynaptic target cells. In flies, ARC knockdown in motor neurons results in a decrease in ARC mRNA and protein in muscles, and leads to impaired expansion of the NMJ, synaptic bouton maturation, and activity-dependent synaptic bouton formation. This phenotype is not rescued by the expression of an ARC construct in muscle alone, nor if the neuronal ARC mRNA construct is missing its 3'-UTR. Overall, these data suggest that it is not just the presence of ARC in presynaptic terminals, but the actual transfer to the postsynaptic region that is required for ARC function.

This exciting piece of information has been transferred to UniProtKB/Swiss-Prot rat and Drosophila ARC entries by means of the classical pathway of expert curation and, as of this release, the updated records are publicly available.

International protein nomenclature guidelines

The European Bioinformatics Institute (EMBL-EBI), the National Center for Biotechnology Information (NCBI), the Protein Information Resource (PIR) and the Swiss Institute for Bioinformatics (SIB) have worked together to produce a shared set of protein naming guidelines. These guidelines are intended for use by anyone who wants to name a protein and aim to promote consistent nomenclature which is indispensable for communication, literature searching and data retrieval. They replace the previous UniProt protein naming guidelines and are available on the UniProt website as part of this release.

UniProtKB news

Cross-references to ComplexPortal

Cross-references have been added to ComplexPortal, a manually curated resource of macromolecular complexes.

ComplexPortal is available at https://www.ebi.ac.uk/complexportal/.

The format of the explicit links is:

Resource abbreviationComplexPortal
Resource identifierResource identifier
Optional information 1Complex name

Example: Q8IY92

Show all entries having a cross-reference to ComplexPortal.

Cross-references to ComplexPortal may be isoform-specific. The general format of isoform-specific cross-references was described in release 2014_03.

h4#a. Text format

Example: Q8IY92

DR   ComplexPortal; CPX-484; SLX4-TERF2 complex.

h4#a. XML format

Example: Q8IY92

<dbReference type="ComplexPortal" id="CPX-484">
  <property type="entry name" value="SLX4-TERF2 complex"/>
</dbReference>

h4#a. RDF format

Example: Q8IY92

uniprot:Q8IY92
  rdfs:seeAlso <//purl.uniprot.org/complexportal/CPX-484> .
<//purl.uniprot.org/complexportal/CPX-484>
  rdf:type up:Resource ;
  up:database <//purl.uniprot.org/database/ComplexPortal> ;
  rdfs:comment "SLX4-TERF2 complex" .

Cross-references to ProteomicsDB

Cross-references have been added to the ProteomicsDB, a human proteome resource.

ProteomicsDB is available at https://www.proteomicsdb.org/.

The format of the explicit links is:

Resource abbreviationProteomicsDB
Resource identifierResource identifier

Example: P41182

Show all entries having a cross-reference to ProteomicsDB.

Cross-references to ProteomicsDB may be isoform-specific. The general format of isoform-specific cross-references was described in release 2014_03.

h4#b. Text format

Example: P41182

DR   ProteomicsDB; 55413; -.
DR   ProteomicsDB; 55414; -. [P41182-2]

h4#b. XML format

Example: P41182

<dbReference type="ProteomicsDB" id="55413"/>
<dbReference type="ProteomicsDB" id="55414">
   <molecule id="P41182-2"/>
</dbReference>

h4#b. RDF format

Example: P41182

uniprot:P41182
  rdfs:seeAlso <//purl.uniprot.org/proteomicsdb/55413> ;
  rdfs:seeAlso <//purl.uniprot.org/proteomicsdb/55414> .
<//purl.uniprot.org/proteomicsdb/55413> rdf:type up:Resource ;
  up:database <//purl.uniprot.org/database/ProteomicsDB> .
<//purl.uniprot.org/proteomicsdb/55414> rdf:type up:Resource ;
  up:database <//purl.uniprot.org/database/ProteomicsDB> ;
  rdfs:seeAlso isoform:P41182-2 .

Cross-references to MoonDB

Cross-references have been added to MoonDB, a database of extreme multifunctional and moonlighting proteins.

MoonDB is available at //moondb.hb.univ-amu.fr.

The format of the explicit links is:

Resource abbreviationMoonDB
Resource identifierUniProtKB accession number
Optional information 1Entry type (“Curated” or “Predicted”)

Example: Q13492

Show all entries having a cross-reference to MoonDB.

h4#c. Text format

Example: Q13492

DR   MoonDB; Q13492; Curated.

h4#c. XML format

Example: Q13492

<dbReference type="MoonDB" id="Q13492">
  <property type="type" value="Curated"/>
</dbReference>

h4#c. RDF format

Example: Q13492

uniprot:Q13492
  rdfs:seeAlso <//purl.uniprot.org/moondb/Q13492> .
<//purl.uniprot.org/moondb/Q13492>
  rdf:type up:Resource ;
  up:database <//purl.uniprot.org/database/MoonDB> ;
  rdfs:comment "Curated" .

Changes to the controlled vocabulary of human diseases

New diseases:

UniProt website news

To improve security and privacy, we have moved our web pages and services from HTTP to HTTPS.

The HTTP protocol does not provide encryption – anyone who can see web traffic between a client (e.g. a web browser) and a server can intercept potentially sensitive information and/or inject malware into users' browsers or operating systems. HTTPS solves this problem by encrypting web traffic between a client and a server in both directions, so that observers cannot intercept or tamper with the client’s requests or the server’s responses. It also provides authentication, ensuring that the client is communicating with the intended server given by the hostname, and not some impostor.

Timeline

We supported separate HTTP and HTTPS services until release 2018_06 (June 20, 2018). From this date, the HTTP traffic is automatically redirected to HTTPS. We intend to maintain these redirects indefinitely, but it is to your advantage to update your applications to use HTTPS as soon as possible, both for performance and security reasons.

Interactive users

If you access our pages only through a Web browser (like Chrome, Firefox, Safari, Internet Explorer, Opera, etc.), the only change after the switchover date is that a green lock icon should appear inside the URL box of your browser, and the web addresses of the pages you visit will start with https://. We recommend that you update your bookmarks and links accordingly.

Programmatic users

Applications that access web servers using // URLs instead of https:// URLs may fail after a switch to HTTPS for the following reasons:

  • Your programming environment’s HTTP facility does not automatically follow redirects from HTTP to HTTPS. Some libraries follow redirections from HTTP to HTTPS, others do not (e.g. Java’s URLConnection).
  • Your application uses HTTP requests other than GET and HEAD. These requests (including especially POST and PUT) will fail with HTTP 403 Forbidden after the switchover date.
  • Your application accesses our servers through a proxy. Check with your proxy vendor about HTTPS support and how to add or update certificates.
  • Your programming environment does not support HTTPS.

After the switchover date, our servers:

  • respond with a server-side redirect (HTTP 301 Moved permanently) to the corresponding HTTPS URL for HTTP GET and HEAD requests
  • respond with HTTP 403 Forbidden and an error message to all HTTP requests other than GET and HEAD (including and especially HTTP POST).

URLs that start with //purl.uniprot.org/, which are used as URIs in the UniProt RDF distribution and SPARQL service, are redirected to the corresponding HTTPS web page when used in a web context.

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our 新疆十一选五开奖结果 to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
  • 湖口县公安局开展集中整治城区飙车行动 2019-03-19
  • 【高清】福州:体验身边的高科技 2019-03-18
  • 新疆伊犁:薰衣草香飘万里 “紫色经济”成产业 2019-03-17
  • 安踏、特步齐发澄清公告 称沽空报告不属实、具有误导性 2019-03-17
  • 曹建明:推进平安中国建设,确保国家长治久安、人民安居乐业 2019-03-16
  • 云南女子饲养小猴子5年 竟是国家一级保护动物熊猴 2019-03-16
  • 图解:习近平的《人民日报》情缘 2019-03-15
  • 是建立市场经济才搞市场经济,不是搞市场经济,我们如何正确认识这个问题? 2019-03-14
  • 全世界人民都要尊重人类社会发展规律即从过去资本主义社会财富私有制经过现代社会财富公有制和私有制并存而发展到未来共产主义社会财富公有制。 2019-03-13
  • 河南焦作市2018年面向国内外引进高层次急需紧缺人才公告 2019-03-13
  • 足球界最丑十大球星:小罗第4!鲁尼第3 里贝里仅第6! ——凤凰网房产 2019-03-12
  • 公安部严查制售高科技作弊专用器材犯罪 2019-03-11
  • 从唐老鸭到疯狂动物城:卡通毛皮七十年 2019-03-10
  • 文化山西:风华长城岁月歌 2019-03-09
  • 世卫组织更新《国际疾病分类》 游戏成瘾列入精神疾病 2019-03-09
  • 276| 567| 412| 971| 299| 836| 191| 662| 850| 993|