Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProt release 2018_06

新疆十一选五开奖结果 www.6nbnc.cn Published June 20, 2018

Headline

Neuronal express mRNA delivery service

In mammals, the activity-regulated cytoskeleton-associated protein ARC is a key regulator of synaptic plasticity, being involved in many aspects of synapse formation, maturation, and plasticity, as well as in learning and memory. ARC expression is known to be induced by synaptic activity and its mRNA accumulates at sites of local synaptic activity where it is locally translated.

ARC originates from the Ty3/Gypsy retrotransposon family and it has retained some retroviral features. Its protein architecture is remarkably similar to that of the capsid domain of human immunodeficiency virus (HIV) GAG protein. GAG proteins are essential for viral infection. They can self-assemble to form capsids and encapsulate genomic RNA via direct sequence-specific interactions. At first glance, these properties do not seem crucial for eukaryotic proteins, but two recent studies unravel a quite unexpected means of neuronal communication, that is reminiscent of viral infection.

The intriguing observation was that ARC protein and mRNA are not only present at synapses, but also enriched in extracellular vesicles (EVs) released by neurons. These EVs are endocytosed by target cells, where ARC mRNA is postsynaptically translated, as has been described both at the Drosophila neuromuscular junction (NMJ), between motor neurons and muscles, and in rat hippocampal neurons. How is this achieved? Presynaptic ARC proteins bind the 3'-UTR of ARC mRNA, oligomerize and form capsid-like structures, in which the mRNA is packaged. These eukaryotic ‘capsids’ are then released by neurons in EVs and they mediate ARC mRNA transfer into postsynaptic target cells. In flies, ARC knockdown in motor neurons results in a decrease in ARC mRNA and protein in muscles, and leads to impaired expansion of the NMJ, synaptic bouton maturation, and activity-dependent synaptic bouton formation. This phenotype is not rescued by the expression of an ARC construct in muscle alone, nor if the neuronal ARC mRNA construct is missing its 3'-UTR. Overall, these data suggest that it is not just the presence of ARC in presynaptic terminals, but the actual transfer to the postsynaptic region that is required for ARC function.

This exciting piece of information has been transferred to UniProtKB/Swiss-Prot rat and Drosophila ARC entries by means of the classical pathway of expert curation and, as of this release, the updated records are publicly available.

International protein nomenclature guidelines

The European Bioinformatics Institute (EMBL-EBI), the National Center for Biotechnology Information (NCBI), the Protein Information Resource (PIR) and the Swiss Institute for Bioinformatics (SIB) have worked together to produce a shared set of protein naming guidelines. These guidelines are intended for use by anyone who wants to name a protein and aim to promote consistent nomenclature which is indispensable for communication, literature searching and data retrieval. They replace the previous UniProt protein naming guidelines and are available on the UniProt website as part of this release.

UniProtKB news

Cross-references to ComplexPortal

Cross-references have been added to ComplexPortal, a manually curated resource of macromolecular complexes.

ComplexPortal is available at https://www.ebi.ac.uk/complexportal/.

The format of the explicit links is:

Resource abbreviationComplexPortal
Resource identifierResource identifier
Optional information 1Complex name

Example: Q8IY92

Show all entries having a cross-reference to ComplexPortal.

Cross-references to ComplexPortal may be isoform-specific. The general format of isoform-specific cross-references was described in release 2014_03.

h4#a. Text format

Example: Q8IY92

DR   ComplexPortal; CPX-484; SLX4-TERF2 complex.

h4#a. XML format

Example: Q8IY92

<dbReference type="ComplexPortal" id="CPX-484">
  <property type="entry name" value="SLX4-TERF2 complex"/>
</dbReference>

h4#a. RDF format

Example: Q8IY92

uniprot:Q8IY92
  rdfs:seeAlso <//purl.uniprot.org/complexportal/CPX-484> .
<//purl.uniprot.org/complexportal/CPX-484>
  rdf:type up:Resource ;
  up:database <//purl.uniprot.org/database/ComplexPortal> ;
  rdfs:comment "SLX4-TERF2 complex" .

Cross-references to ProteomicsDB

Cross-references have been added to the ProteomicsDB, a human proteome resource.

ProteomicsDB is available at https://www.proteomicsdb.org/.

The format of the explicit links is:

Resource abbreviationProteomicsDB
Resource identifierResource identifier

Example: P41182

Show all entries having a cross-reference to ProteomicsDB.

Cross-references to ProteomicsDB may be isoform-specific. The general format of isoform-specific cross-references was described in release 2014_03.

h4#b. Text format

Example: P41182

DR   ProteomicsDB; 55413; -.
DR   ProteomicsDB; 55414; -. [P41182-2]

h4#b. XML format

Example: P41182

<dbReference type="ProteomicsDB" id="55413"/>
<dbReference type="ProteomicsDB" id="55414">
   <molecule id="P41182-2"/>
</dbReference>

h4#b. RDF format

Example: P41182

uniprot:P41182
  rdfs:seeAlso <//purl.uniprot.org/proteomicsdb/55413> ;
  rdfs:seeAlso <//purl.uniprot.org/proteomicsdb/55414> .
<//purl.uniprot.org/proteomicsdb/55413> rdf:type up:Resource ;
  up:database <//purl.uniprot.org/database/ProteomicsDB> .
<//purl.uniprot.org/proteomicsdb/55414> rdf:type up:Resource ;
  up:database <//purl.uniprot.org/database/ProteomicsDB> ;
  rdfs:seeAlso isoform:P41182-2 .

Cross-references to MoonDB

Cross-references have been added to MoonDB, a database of extreme multifunctional and moonlighting proteins.

MoonDB is available at //moondb.hb.univ-amu.fr.

The format of the explicit links is:

Resource abbreviationMoonDB
Resource identifierUniProtKB accession number
Optional information 1Entry type (“Curated” or “Predicted”)

Example: Q13492

Show all entries having a cross-reference to MoonDB.

h4#c. Text format

Example: Q13492

DR   MoonDB; Q13492; Curated.

h4#c. XML format

Example: Q13492

<dbReference type="MoonDB" id="Q13492">
  <property type="type" value="Curated"/>
</dbReference>

h4#c. RDF format

Example: Q13492

uniprot:Q13492
  rdfs:seeAlso <//purl.uniprot.org/moondb/Q13492> .
<//purl.uniprot.org/moondb/Q13492>
  rdf:type up:Resource ;
  up:database <//purl.uniprot.org/database/MoonDB> ;
  rdfs:comment "Curated" .

Changes to the controlled vocabulary of human diseases

New diseases:

UniProt website news

To improve security and privacy, we have moved our web pages and services from HTTP to HTTPS.

The HTTP protocol does not provide encryption – anyone who can see web traffic between a client (e.g. a web browser) and a server can intercept potentially sensitive information and/or inject malware into users' browsers or operating systems. HTTPS solves this problem by encrypting web traffic between a client and a server in both directions, so that observers cannot intercept or tamper with the client’s requests or the server’s responses. It also provides authentication, ensuring that the client is communicating with the intended server given by the hostname, and not some impostor.

Timeline

We supported separate HTTP and HTTPS services until release 2018_06 (June 20, 2018). From this date, the HTTP traffic is automatically redirected to HTTPS. We intend to maintain these redirects indefinitely, but it is to your advantage to update your applications to use HTTPS as soon as possible, both for performance and security reasons.

Interactive users

If you access our pages only through a Web browser (like Chrome, Firefox, Safari, Internet Explorer, Opera, etc.), the only change after the switchover date is that a green lock icon should appear inside the URL box of your browser, and the web addresses of the pages you visit will start with https://. We recommend that you update your bookmarks and links accordingly.

Programmatic users

Applications that access web servers using // URLs instead of https:// URLs may fail after a switch to HTTPS for the following reasons:

  • Your programming environment’s HTTP facility does not automatically follow redirects from HTTP to HTTPS. Some libraries follow redirections from HTTP to HTTPS, others do not (e.g. Java’s URLConnection).
  • Your application uses HTTP requests other than GET and HEAD. These requests (including especially POST and PUT) will fail with HTTP 403 Forbidden after the switchover date.
  • Your application accesses our servers through a proxy. Check with your proxy vendor about HTTPS support and how to add or update certificates.
  • Your programming environment does not support HTTPS.

After the switchover date, our servers:

  • respond with a server-side redirect (HTTP 301 Moved permanently) to the corresponding HTTPS URL for HTTP GET and HEAD requests
  • respond with HTTP 403 Forbidden and an error message to all HTTP requests other than GET and HEAD (including and especially HTTP POST).

URLs that start with //purl.uniprot.org/, which are used as URIs in the UniProt RDF distribution and SPARQL service, are redirected to the corresponding HTTPS web page when used in a web context.

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our 新疆十一选五开奖结果 to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
  • 廉洁勤政,不应只是挂在口头上;一味贪图享乐,对不起纳税民众. 2018-11-16
  • 在深入推动长江经济带发展座谈会上的讲话 2018-11-16
  • 鄱阳湖花海:文明仍应成为最美风景 2018-11-15
  • 夏季养生小常识 多吃酸食少吃冷 让你更健康-美食资讯 2018-11-15
  • 内蒙古扶贫开发办副主任王幂生涉嫌严重违纪违法被查 2018-11-14
  • 空调还装墙壁上?聪明人都是往这里装,好看又省地 ——凤凰网房产 2018-11-13
  • 四年了,球迷们又“长大一岁” 2018-11-13
  • 六安农副产品平价商店端午让利优惠 2018-11-12
  • 关于人类所有的知识问题,其实都是社会问题。就“社会”两个字。 2018-11-12
  • 南京灵谷寺萤火虫飞舞 宛如童话世界 2018-11-11
  • 朔州启动桑干河“清河行动” 2018-11-11
  • 400年来旷日持久的一桩公案:《西游记》作者真的是吴承恩吗? 2018-11-10
  • 中央党校赵磊教授作“大国崛起中的软实力建设”专题报告 2018-11-09
  • 不可思议!日本八幡平现“龙眼”奇景 2018-11-09
  • 苏州平江路,市中心的历史古迹!文章中国国家地理网 2018-11-08
  • 97| 349| 865| 476| 977| 209| 706| 193| 857| 159|