Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProt release 2018_04

新疆十一选五开奖结果 www.6nbnc.cn Published April 25, 2018

Headline

The Matrix (enzymes) Reloaded

Collagen is the major protein that stitches together animal tissues, and is the most abundant protein in mammals, making up to 25-35% of our body weight. It comprises three individual protein molecules which coil together to form tropocollagen fibers which in turn make microfibrils. Collagen is extremely stable and extremely ancient; collagen fragments have been sequenced from 80 million year old dinosaurs, such as Brachylophosaurus canadensis and Tyrannosaurus rex, and is found in all extant metazoans. The breakdown of collagen is essential to permit tissue growth, and all animals have the ability to metabolize collagen in a very controlled way by cutting a single site. Infectious bacteria, such as gas gangrene-causing Clostridium perfringens and Hathewaya histolytica, on the other hand digest collagen indiscriminately, using collagenases with both endopeptidase and tripeptidylcarboxypeptidase activities. This rampant activity causes massive tissue disruption, favoring bacterial colonization and virulence, and is obviously severely problematic in a clinical setting.

Despite their different approaches to collagen degradation (cautious versus gung-ho), mammalian and clostridial collagenases have similar enzymatic mechanisms and many inhibitors work on both types of collagenases, making them unsuitable for antibacterial therapy. Recent work by Sch?nauer et al. has found promising new molecules that inhibit only bacterial and not mammalian collagenases, pointing to a possible way to block bacterial collagenase action in a wound setting for example. By not attacking the bacteria directly, these inhibitors should provide novel, non-selective ways to treat some of the damage inflicted by these bacteria, while minimizing potential resistance. While these inhibitors are undoubtedly very useful, there are also many applications in which potentially undesirable bacterial collagenase activities are actively exploited. The H.histolytica collagenases (ColG and ColH) are used to isolate pancreatic islet cells for transplantation, remove retained placenta in cattle and horses, to debride wounds, ulcers and severely burned patients (SANTYL Ointment, Smith and Nephew, Inc.), and to treat human diseases caused by abnormal accumulation of collagen plaques such as Dupuytren’s disease and Peyronie’s disease (Xiaflex, Endo Pharmaceuticals, Inc.). Dupuytren’s disease is an abnormal deposition of collagen in the hand that causes permanent contraction. In Peyronie’s disease, collagen forms fibrous plaques in the penis, restricting erection. Collagenase injection relieves this accumulation, leading to an increased quality of life. The collagen-binding domain of collagenases when attached to other proteins, promotes their retention at injection sites for as long as 10 days. Although this is far from the only example of a repurposed enzyme (think of Botox, another clostridial protein), it is fascinating how a protein class that can be so dangerous to life, when harnessed, can be so very helpful.

As of this release 3 clostridial collagenases have been expertly updated in UniProtKB/Swiss-Prot.

Cross-references to GlyConnect

Cross-references have been added to the GlyConnect database and protein glycosylation platform.

GlyConnect is available at https://glyconnect.expasy.org.

The format of the explicit links is:

Resource abbreviationGlyConnect
Resource identifierResource identifier

Example: P00742

Show all entries having a cross-reference to GlyConnect.

Cross-references to GlyConnect may be isoform-specific. The general format of isoform-specific cross-references was described in release 2014_03.

Text format

Example: P00742

DR   GlyConnect; 102; -.

XML format

Example: P00742

<dbReference type="GlyConnect" id="102"/>

RDF format

Example: P00742

uniprot:P00742
  rdfs:seeAlso <//purl.uniprot.org/glyconnect/102> .
<//purl.uniprot.org/glyconnect/102>
  rdf:type up:Resource ;
  up:database <//purl.uniprot.org/database/GlyConnect> .

Changes to the controlled vocabulary of human diseases

New diseases:

Modified diseases:

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our 新疆十一选五开奖结果 to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
  • 中国是亚洲和平的基石 2019-06-25
  • “藏族院士”多吉:大自然是慷慨的,也是有原则的 2019-06-25
  • 暴瘦50斤,70岁的她爱穿比基尼,活得比少女还滋润! 2019-06-24
  • 比利时并不轻松地击败巴拿马 2019-06-23
  • 我们说国企产权不明晰就是公有制搞市场经济才会出现不明晰产权,这就说明我们还没有明晰产权建立市场经济就在搞市场经济,才会出现产权不明晰这个问题,才会导致公有制变成 2019-06-22
  • 长安街知事:中央督查组对党政一把手动真格 2019-06-21
  • “三聚氰胺”受害儿童父亲敲诈案再审:不构成犯罪 2019-06-20
  • 县名解析:晋中介休市地名来历 2019-06-19
  • 专题--河北频道--人民网 2019-06-18
  • 鹰潭高新区思想解放添发展动力 2019-06-18
  • 中粮名庄荟国际酒业有限公司总经理李士祎做客人民网 2019-06-17
  • 在学习中进步。[奋斗] 2019-06-16
  • [视频]习近平打老虎动漫续集:当官要对自己狠一点 2019-06-15
  • 为何“最美晚霞”总在暴雨后? 2019-06-14
  • 发展中国家的市场经济,一般会落入:资本市场、来料加工、吃喝玩乐消费、房地产疯涨,等经济基础不牢的“中等收入陷阱”。 2019-06-14
  • 足球竞彩网上怎么买 三肖中特赔率 江西时时彩万能七 大乐透走势图500期和值走势图 浙江快乐12选5下载 20选5对奖方法 特码资料 1988年福彩开奖结果 江西多乐彩任五最大遗漏数据 菲彩娱乐城博彩网 淘宝合买大厅 96期三肖中特免费公开 四川时时彩开奖视频直播 湖南快乐十分开奖视频走势图 微信猜拳平局怎么办