The Universal Protein Resource (UniProt) is a comprehensive resource for protein sequence and annotation data. The UniProt databases are the UniProt Knowledgebase (UniProtKB), the UniProt Reference Clusters (UniRef), and the UniProt Archive (UniParc).
UniProt is a collaboration between the European Bioinformatics Institute (EMBL-EBI), the SIB Swiss Institute of Bioinformatics and the Protein Information Resource (PIR). Across the three institutes more than 100 people are involved through different tasks such as database curation, software development and support.
EMBL-EBI and SIB together used to produce Swiss-Prot and TrEMBL, while PIR produced the Protein Sequence Database (PIR-PSD). These two data sets coexisted with different protein sequence coverage and annotation priorities. TrEMBL (Translated EMBL Nucleotide Sequence Data Library) was originally created because sequence data was being generated at a pace that exceeded Swiss-Prot’s ability to keep up. Meanwhile, PIR maintained the PIR-PSD and related databases, including iProClass, a database of protein sequences and curated families. In 2002 the three institutes decided to pool their resources and expertise and formed the UniProt consortium.
UniProt is supported by the National Eye Institute (NEI), National Human Genome Research Institute (NHGRI), National Heart, Lung, and Blood Institute (NHLBI), National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of General Medical Sciences (NIGMS), and National Institute of Mental Health (NIMH) of the National Institutes of Health (NIH) under grant U24HG007822. Additional support for the EMBL-EBI’s involvement in UniProt comes from European Molecular Biology Laboratory (EMBL), the British Heart Foundation (BHF) (RG/13/5/30112), the Parkinson’s Disease United Kingdom (PDUK) GO grant G-1307, and the NIH GO grant U41HG02273. UniProt activities at the SIB are additionally supported by the Swiss Federal Government through the State Secretariat for Education, Research and Innovation SERI. PIR’s UniProt activities are also supported by the NIH grants R01GM080646, G08LM010720, and P20GM103446, and the National Science Foundation (NSF) grant DBI-1062520.
UniProt has been supported by the NIH grants U01HG02712 (2002-2010) and U41HG006104 (2010-2014).
UniProt activities at EMBL-EBI have benefited from the FP7 SLING project (2009-2012, contract number 226073) and a British Heart Foundation grant (SP/07/007/23671).
UniProt activities at SIB have benefited from EC support through the FP6 FELICS project (2006-2009, contract number 021902), and the FP7 projects SLING (2009-2012, contract number 226073), GEN2PHEN (2009-2013, contract number 200754), and MICROME (2009-2013, contract number 222886-2).
UniProt activities at PIR have benefited from NIH grants HHSN266200400061C (2004-2009), R01GM080646 (2007-2011), R01GM080646-04S2 (2009-2012), R01GM080646-07S1 (2012), and P20RR016472-09S2 (2009-2011), NSF grants DBI-0138188 (2002-2005) and IIS-0430743 (2004-2007), and UNIDEL Foundation award (2010-2012).
Printable reference card for the UniProt databases
Contact the UniProt consortium members
European Bioinformatics Institute (EMBL-EBI)
Wellcome Trust Genome Campus
Hinxton Cambridge CB10 1SD
Phone: (+44 1223) 494 444
Fax: (+44 1223) 494 468
SIB Swiss Institute of Bioinformatics
Centre Medical Universitaire
1, rue Michel Servet
1211 Geneva 4
Phone: (+41 22) 379 50 50
Fax: (+41 22) 379 58 58
Protein Information Resource (PIR)
Georgetown University Medical Center
3300 Whitehaven Street NW
Washington, DC 20007
United States of America
Phone: (+1 202) 687 1039
Fax: (+1 202) 687 0057